Heterotrimeric G-proteins and their role in opioid receptor function

Fábián, Gabriella: Heterotrimeric G-proteins and their role in opioid receptor function. Acta biologica Szegediensis, (45) 1-4. pp. 13-21. (2001)

[img] Cikk, tanulmány, mű
4513.pdf

Download (1MB)

Abstract

Heterotrimeric G-proteins are signal transducers of heptahelical receptors. They consist of a and bg subunits, both capable of interacting with several different effectors. Specific domains in their structures enable them to connect different intracellular signaling cascades, such as the adenylyl cyclase, phosphoinositol-bisphosphate or MAP kinase pathways. Their activity is synchronized by several components, one of them being a new protein family termed RGS (regulators of G-protein signaling). Members of this family inhibit the G-protein function. The intracellular localization of G-proteins indicates their role in plasma membrane-independent processes. Opioid receptors transmit their signals mainly via Gi/o proteins. Although the heterogeneity of opioid ligands (peptides and alkaloids) and their receptors (m, d, k and suggested subtypes in these classes) reveals a complicated picture, their unique characteristic of a high dependence capacity can not be explained without the analysis of the G-protein function.

Item Type: Article
Journal or Publication Title: Acta biologica Szegediensis
Date: 2001
Volume: 45
Number: 1-4
Page Range: pp. 13-21
ISSN: 1588-385X
Language: angol
Heading title: Review articles
Uncontrolled Keywords: Természettudomány, Biológia
Additional Information: Bibliogr.: p. 19-21.; Abstract
Date Deposited: 2016. Oct. 17. 09:25
Last Modified: 2018. May. 28. 10:22
URI: http://acta.bibl.u-szeged.hu/id/eprint/22441

Actions (login required)

View Item View Item