Fábián Gabriella: Heterotrimeric G-proteins and their role in opioid receptor function. In: Acta biologica Szegediensis, (45) 1-4. pp. 13-21. (2001)
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Absztrakt (kivonat)
Heterotrimeric G-proteins are signal transducers of heptahelical receptors. They consist of a and bg subunits, both capable of interacting with several different effectors. Specific domains in their structures enable them to connect different intracellular signaling cascades, such as the adenylyl cyclase, phosphoinositol-bisphosphate or MAP kinase pathways. Their activity is synchronized by several components, one of them being a new protein family termed RGS (regulators of G-protein signaling). Members of this family inhibit the G-protein function. The intracellular localization of G-proteins indicates their role in plasma membrane-independent processes. Opioid receptors transmit their signals mainly via Gi/o proteins. Although the heterogeneity of opioid ligands (peptides and alkaloids) and their receptors (m, d, k and suggested subtypes in these classes) reveals a complicated picture, their unique characteristic of a high dependence capacity can not be explained without the analysis of the G-protein function.
| Mű típusa: | Cikk, tanulmány, mű |
|---|---|
| Rovatcím: | Review articles |
| Befoglaló folyóirat/kiadvány címe: | Acta biologica Szegediensis |
| Dátum: | 2001 |
| Kötet: | 45 |
| Szám: | 1-4 |
| ISSN: | 1588-385X |
| Oldalak: | pp. 13-21 |
| Nyelv: | angol |
| Befoglaló mű URL: | http://acta.bibl.u-szeged.hu/39243/ |
| Kulcsszavak: | Természettudomány, Biológia |
| Megjegyzések: | Bibliogr.: p. 19-21.; Abstract |
| Feltöltés dátuma: | 2016. okt. 17. 09:25 |
| Utolsó módosítás: | 2021. ápr. 13. 12:43 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/22441 |
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