Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron

Kása, Péter: Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron. In: Acta biologica Szegediensis, (48) 1-4. pp. 1-6. (2004)

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Abstract

It is assumed that the amyloid-beta peptide (Ab) contributes to the neurodegeneration in Alzheimer’s disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Ab protein may be an activator of caspase-3 and could initiate a series of cascade events, which results in neurofibrillary degeneration in a postsynaptic cell. We report here that the axonic Ab in the AD brain may be associated with caspase-3 activation. Our data suggest that caspase-3 in fact has a significant role in the widespread neuronal cell death that occurs in AD brain. A subset of pyramidal cells in hippocampus area CA1 demonstrated widespread accumulation of tau-protein. Individual postsynaptic neurons contained intracellular activated caspase-3 and were co-localized with neurofibrillary tangles. The results presented here support the suggestion that caspase-3 activation may lead to the neuronal cell death associated with AD. However, we are aware that, besides Ab, other factors too may initiate a series of events which lead to the development of neurofibrillary tangles in the postsynaptic neurons.

Item Type: Article
Heading title: Articles
Journal or Publication Title: Acta biologica Szegediensis
Date: 2004
Volume: 48
Number: 1-4
ISSN: 1588-385X
Page Range: pp. 1-6
Language: angol
Related URLs: http://acta.bibl.u-szeged.hu/39247/
Uncontrolled Keywords: Természettudomány, Biológia
Additional Information: Bibliogr.: 6. p.; Abstract
Date Deposited: 2016. Oct. 17. 09:24
Last Modified: 2021. Apr. 13. 11:36
URI: http://acta.bibl.u-szeged.hu/id/eprint/22626

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