Kása Péter: Presynaptic axonal amyloid-β induces caspase-3 activation and neurodegeneration in the postsynaptic neuron. In: Acta biologica Szegediensis, (48) 1-4. pp. 1-6. (2004)
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Absztrakt (kivonat)
It is assumed that the amyloid-beta peptide (Ab) contributes to the neurodegeneration in Alzheimer’s disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Ab protein may be an activator of caspase-3 and could initiate a series of cascade events, which results in neurofibrillary degeneration in a postsynaptic cell. We report here that the axonic Ab in the AD brain may be associated with caspase-3 activation. Our data suggest that caspase-3 in fact has a significant role in the widespread neuronal cell death that occurs in AD brain. A subset of pyramidal cells in hippocampus area CA1 demonstrated widespread accumulation of tau-protein. Individual postsynaptic neurons contained intracellular activated caspase-3 and were co-localized with neurofibrillary tangles. The results presented here support the suggestion that caspase-3 activation may lead to the neuronal cell death associated with AD. However, we are aware that, besides Ab, other factors too may initiate a series of events which lead to the development of neurofibrillary tangles in the postsynaptic neurons.
| Mű típusa: | Cikk, tanulmány, mű |
|---|---|
| Rovatcím: | Articles |
| Befoglaló folyóirat/kiadvány címe: | Acta biologica Szegediensis |
| Dátum: | 2004 |
| Kötet: | 48 |
| Szám: | 1-4 |
| ISSN: | 1588-385X |
| Oldalak: | pp. 1-6 |
| Nyelv: | angol |
| Befoglaló mű URL: | http://acta.bibl.u-szeged.hu/39247/ |
| Kulcsszavak: | Természettudomány, Biológia |
| Megjegyzések: | Bibliogr.: 6. p.; Abstract |
| Feltöltés dátuma: | 2016. okt. 17. 09:24 |
| Utolsó módosítás: | 2021. ápr. 13. 11:36 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/22626 |
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