Role of membrane redox in aging-related diseases

Morré, Dorothy M. and Morré, D. James: Role of membrane redox in aging-related diseases. In: Acta biologica Szegediensis, (50) 1-2. pp. 67-69. (2006)

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A number of different ECTO-NOX forms have been described as being connected with aging-related diseases. The constitutive form, CNOX, serves as a terminal oxidase of plasma membrane electron transport and functions in the growth process. tNOX is present in addition to CNOX on the surface of all cancer cells and contributes to the unregulated growth characteristic of cancer cells. An age-related ECTO-NOX, arNOX, generates superoxide and may contribute to age-related generation of reactive oxygen species. ECTO-NOX proteins and prions share properties in common as do amyloid-forming proteins of various neurodegenerative disorders. A better understanding of ECTO-NOX proteins may lead to new therapeutic strategies for these several age-related disorders.

Item Type: Article
Heading title: Proceedings
Journal or Publication Title: Acta biologica Szegediensis
Date: 2006
Volume: 50
Number: 1-2
ISSN: 1588-385X
Page Range: pp. 67-69
Language: angol
Event Title: International Conference on Membrane Redox Systems and Their Role in Biological Stress and Disease, 8., 2006, Szeged
Uncontrolled Keywords: Természettudomány, Biológia
Additional Information: Bibliogr.: p. 68-69.; Abstract
Date Deposited: 2016. Oct. 17. 09:24
Last Modified: 2018. May. 25. 13:11

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