Blood-brain carrier co-culture models to study nanoparticle penetration : focus on co-culture systems

Veszelka, Szilvia and Bocsik, Alexandra and Walter, Fruzsina and Hantosi, Dóra and Deli, Mária A: Blood-brain carrier co-culture models to study nanoparticle penetration : focus on co-culture systems. Acta biologica Szegediensis, (59). pp. 157-168. (2015)

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Abstract

The blood-brain barrier, as a physical, active transport and metabolic barrier represents the main obstacle in the treatment of central nervous system diseases. The field of nanoparticle delivery systems is rapidly developing and nanocarriers seem to be promising for drug delivery or targeting to the brain. For testing the toxicity, uptake and transcellular transport of nanoparticles culture models of the blood-brain barrier are widely used, including immortalized brain endothelial cell lines, primary brain endothelial cells in static or dynamic culture conditions, and in co-culture systems with glial cells and/or pericytes. This mini-review gives a brief summary of blood-brain barrier co-culture models that were used for testing nanocarriers, the types of different nanoparticle systems that were examined on blood-brain barrier models, and the advantages, limitations and suitability of the blood-brain barrier models for nanoparticle penetration studies.

Item Type: Article
Journal or Publication Title: Acta biologica Szegediensis
Date: 2015
Volume: 59
Page Range: pp. 157-168
ISSN: 1588-385X
Language: angol
Heading title: Reviews
Uncontrolled Keywords: Vérkeringés agy
Additional Information: Bibliogr.: p. 165-168.
Date Deposited: 2016. Oct. 17. 10:36
Last Modified: 2018. May. 25. 12:02
URI: http://acta.bibl.u-szeged.hu/id/eprint/36022

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