Genetics, molecular and cell biology of apoptotic cell death

Fajka-Boja, Roberta and Czibula, Ágnes and Monostori, Éva: Genetics, molecular and cell biology of apoptotic cell death. In: Acta biologica Szegediensis, (59). pp. 143-156. (2015)

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Apoptotic cell death is an integral part of development and cell turnover in multicellular organisms. Since early 1970’s, when apoptosis was defined on morphological basis, plethora of genes has been identified participating in initiation, execution and regulation of cell death. This article reviews these latest advances and describes our present understanding of the sequential events of apoptotic cell death, from the early steps of death receptor initiated and mitochondrial pathways to activation of caspases, and finally, the proper corpse clearance. It also discusses dysregulation of apoptosis, leading to various pathologies, such as cancer, autoimmune disease and neurodegenerative disorders.

Item Type: Article
Heading title: Reviews
Journal or Publication Title: Acta biologica Szegediensis
Date: 2015
Volume: 59
ISSN: 1588-385X
Page Range: pp. 143-156
Language: angol
Uncontrolled Keywords: Sejtélettan, Programozott sejthalál
Additional Information: Bibliogr.: p. 153-156.
Date Deposited: 2016. Oct. 17. 10:36
Last Modified: 2018. May. 25. 11:56

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