Ádám Éva; Hajdu Anita; Nagy Ferenc; Viczián András: Optogenetics : past, present and future. In: Acta biologica Szegediensis, (59). pp. 105-119. (2015)
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Absztrakt (kivonat)
The term ‘optogenetics’ was introduced into the scientific literature less than a decade ago by Karl Deisseroth, developer of pioneering optogenetic techniques, who defined optogenetics as “the combination of genetic and optical methods to achieve gain or loss of function of well-defined events in specific cells of living tissue”. Since then this new field of biology has become a very exciting and rapidly developing area producing hundreds of scientific publications. New methods and tools have been developed and long-sought answers found in these new experimental systems. Discussion and full elaboration of every optogenetic approach and application are beyond the scope of this review, instead, it gives a short insight to (i) how light can be used to manipulate the membrane potential of various cells; (ii) how light-sensitive proteins can be used to regulate targeted gene expression, and (iii) how controlled release or spatio-temporal targeting of certain molecules can be modulated by light. Besides, the most widely used light-sensor proteins, including their structure, working mechanism and their involvement in existing optogenetic applications are also discussed.
| Mű típusa: | Cikk, tanulmány, mű |
|---|---|
| Rovatcím: | Reviews |
| Befoglaló folyóirat/kiadvány címe: | Acta biologica Szegediensis |
| Dátum: | 2015 |
| Kötet: | 59 |
| ISSN: | 1588-385X |
| Oldalak: | pp. 105-119 |
| Nyelv: | angol |
| Kulcsszavak: | Optogenetika, Idegélettan agy |
| Megjegyzések: | Bibliogr.: p. 115-119. |
| Feltöltés dátuma: | 2016. okt. 17. 10:37 |
| Utolsó módosítás: | 2018. máj. 25. 11:54 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/36058 |
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