Potential applications of filamentous fungus derived β-defensin-like antifungal proteins in agriculture

Galgóczy, László and Virágh, Máté and Kovács, Laura and Tóth, Liliána and Vágvölgyi, Csaba: Potential applications of filamentous fungus derived β-defensin-like antifungal proteins in agriculture. Review on agriculture and rural development, (2) 1. pp. 217-223. (2013)

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Abstract

Many filamentous fungi are postharvest and destructive plant pathogens and are thus responsible for enormous crop losses worldwide. The antifungal proteins secreted by filamentous fungi are promising agents for prevention of fungal diseases in the agriculture. The extracellular β-defensin-like antifungal proteins derived from ascomycetous filamentous fungal species are especially interesting in this respect because of their chemical and biological properties. The main features of these extracellular proteins are a low molecular mass, a basic character, and the presence of 6-8 cysteine residues and several intramolecular disulfide bonds which provide them with a high stability against protease degradation, high temperature and within a broad pH range. The tertiary structure of these proteins is very similar to the β-defensins, it contains five antiparallel β-sheets connected by three loops. In spite of the fact that they are very different in their amino acid sequences; conserved homologous regions can be identified. Based on it they can be divided into two main groups: peptides which contain the Penicillium chrysogenum antifungal protein (PAF) cluster in their amino acid sequences, and peptides with Penicillium brevicompactum bubble protein (BP) cluster. Both of them have a potent antifungal activity, but the peptides with PAF-cluster are effective against filamentous fungi. These proteins secreted by taxonomical distinct species cause similar symptoms on the susceptible fungus, but they have different mode of action and species specificity, nevertheless, their structure is very similar. They have high stability and efficacy; their limited toxicity and low costs of production could make them suitable for use in practical respects in agricultural fields, especially in plant protection on the field and crop protection after the harvest.

Item Type: Article
Journal or Publication Title: Review on agriculture and rural development
Date: 2013
Volume: 2
Number: 1
Page Range: pp. 217-223
ISSN: 2063-4803
Uncontrolled Keywords: Gombák - növénybetegségek, Mikrobiológia
Additional Information: Bibliogr.: p. 221-223. ; Összefoglalás angol nyelven
Date Deposited: 2018. Jun. 15. 16:13
Last Modified: 2018. Jul. 26. 10:15
URI: http://acta.bibl.u-szeged.hu/id/eprint/55256

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