Ienaşcu Ioana M. C.; Căta Adina; Ștefănuț Mariana Nela; Tănasie Cristian; Popescu Iuliana M.: Synthesis and characterization of some potential biologically active niclosamide derivatives.
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Compounds with 2-hydroxy-benzanilide core are recognized for their biological effects. Niclosamide, in particular, is authorized for its anti-helmintic properties and, recently, demonstrated additional effects like antitumoral and antiviral ones. Thus, we considered worthwhile to synthesize some niclosamide derivatives, which could possess enhanced biological activity. Starting from 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide and methyl/ethyl α-halogenated acid esters were obtained methyl/ethyl esters. In order to prove the structural identity of the newly synthesized compounds, modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR) were used. The data obtained for the analyzed compounds proved their identity and confirm their structure.
| Mű típusa: | Konferencia vagy workshop anyag |
|---|---|
| Befoglaló folyóirat/kiadvány címe: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Dátum: | 2015 |
| Kötet: | 21 |
| ISBN: | 978-963-306-411-5 |
| Oldalak: | pp. 168-171 |
| Konferencia neve: | International Symposium on Analytical and Environmental Problems (21.) (2015) (Szeged) |
| Befoglaló mű URL: | http://acta.bibl.u-szeged.hu/55892/ |
| Kulcsszavak: | Biokémia, Elektrokémia, Kémia |
| Megjegyzések: | Bibliogr.: 171. p. ; összefoglalás angol nyelven |
| Feltöltés dátuma: | 2018. dec. 05. 14:38 |
| Utolsó módosítás: | 2022. aug. 08. 15:47 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/55953 |
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