Synthesis and characterization of some potential biologically active niclosamide derivatives

Ienaşcu, Ioana M. C. and Căta, Adina and Ștefănuț, Mariana Nela and Tănasie, Cristian and Popescu, Iuliana M.: Synthesis and characterization of some potential biologically active niclosamide derivatives. Proceedings of the International Symposium on Analytical and Environmental Problems, (21). pp. 168-171. (2015)

[img] Cikk, tanulmány, mű
proceedings_of_isaep_2015_168-171.pdf

Download (119kB)

Abstract

Compounds with 2-hydroxy-benzanilide core are recognized for their biological effects. Niclosamide, in particular, is authorized for its anti-helmintic properties and, recently, demonstrated additional effects like antitumoral and antiviral ones. Thus, we considered worthwhile to synthesize some niclosamide derivatives, which could possess enhanced biological activity. Starting from 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide and methyl/ethyl α-halogenated acid esters were obtained methyl/ethyl esters. In order to prove the structural identity of the newly synthesized compounds, modern physico-chemical methods (FTIR, 1H-NMR, 13C-NMR) were used. The data obtained for the analyzed compounds proved their identity and confirm their structure.

Item Type: Article
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2015
Volume: 21
Page Range: pp. 168-171
ISBN: 978-963-306-411-5
Uncontrolled Keywords: Biokémia, Elektrokémia, Kémia
Additional Information: Bibliogr.: 171. p. ; összefoglalás angol nyelven
Date Deposited: 2018. Dec. 05. 14:38
Last Modified: 2018. Dec. 05. 14:38
URI: http://acta.bibl.u-szeged.hu/id/eprint/55953

Actions (login required)

View Item View Item