High-performance liquid chromatographic study on the enantioseparation of fluorine containing cyclic amino acid derivatives

Orosz, Tímea and Lajkó, Gyula and Grecsó, Nóra and Kiss, Lóránd and Forró, Enikő and Fülöp, Ferenc and Péter, Antal and Ilisz, István: High-performance liquid chromatographic study on the enantioseparation of fluorine containing cyclic amino acid derivatives. Proceedings of the International Symposium on Analytical and Environmental Problems, (22). pp. 399-401. (2016)

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Abstract

The stereoisomers of several fluorinated cyclic β 3 -amino acid derivatives and their nonfluorinated counterparts were separated on chiral stationary phases containing as chiral selectors cellulose tris-(3,5-dimethylphenyl carbamate), cellulose tris-(3-chloro-4-methylphenyl carbamate), cellulose tris-(4-methylbenzoate), cellulose tris-(4-chloro-3-methylphenyl carbamate), amylose tris-(3,5-dimethylphenyl carbamate) or amylose tris-(5-chloro-2-methylphenyl carbamate). The enantioseparations were carried out in normal-phase mode with n-hexane/alcohol/alkylamine mobile phases in the temperature range 5–40 °C. The effects of the mobile phase composition, the nature and concentration of the alcohol and alkylamine additives, the structures of the analytes and temperature on the separations were investigated.

Item Type: Article
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2016
Volume: 22
Page Range: pp. 399-401
ISBN: 978-963-306-507-5
Uncontrolled Keywords: Analitikai kémia, Gyógyszerkémia
Additional Information: Bibliogr.: 401. p. ; összefoglalás angol nyelven
Date Deposited: 2018. Dec. 13. 10:55
Last Modified: 2018. Dec. 13. 10:55
URI: http://acta.bibl.u-szeged.hu/id/eprint/56129

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