Enantioseparation of cyclic β-amino acids on ion-exchangerbased chiral stationary phases

Orosz, Tímea and Forró, Enikő and Fülöp, Ferenc and Lindner, Wolfgang and Lajkó, Gyula and Bajtai, Attila and Péter, Antal and Ilisz, István: Enantioseparation of cyclic β-amino acids on ion-exchangerbased chiral stationary phases. Proceedings of the International Symposium on Analytical and Environmental Problems, (23). pp. 67-69. (2017)

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Abstract

In the present work a direct HPLC method is described for the separation of the stereoisomers of the ampholytic non-methylated, N-methyl-, N-dimethyl- and N-amidino protected cyclic βamino acids through the application of novel Cinchona alkaloid and sulfonic acid-based zwitterionic chiral stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™. The enantioseparations were carried out in polar-ionic mobile phase mode in the temperature range 5–40 °C. The effects of the composition of the bulk solvent, the acid and base additive, the temperature, the structures of the ampholytic analytes on the separations were investigated.

Item Type: Article
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2017
Volume: 23
Page Range: pp. 67-69
ISBN: 978-963-306-563-1
Uncontrolled Keywords: Analitikai kémia
Additional Information: Bibliogr.: 69. p. ; összefoglalás angol nyelven
Date Deposited: 2018. Dec. 14. 08:37
Last Modified: 2018. Dec. 14. 08:37
URI: http://acta.bibl.u-szeged.hu/id/eprint/56157

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