Synthesis of novel Pt complexes with α-glyoximes, schiff bases and their physical-chemical and biological study

Várhelyi, Csaba and Szalay, Roland and Pokol, György and Goga, Firuţa and Papp, Judit and Szabó, Pál and Huszthy, Péter and Golban, Ligia Mirabela and Várhelyi, Melinda and Lang, Laura: Synthesis of novel Pt complexes with α-glyoximes, schiff bases and their physical-chemical and biological study. In: Proceedings of the International Symposium on Analytical and Environmental Problems, (24). pp. 26-30. (2018)

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Abstract

Platinum-complexes permanently play an important role in the medical treatment of tumor cells. Since Pt has a soft-type Lewis acidic character, it forms the most stable complexes with S, P, N and I donor atoms, resulting planar (cisplatine) or octahedral (satraplatine) arrangement of ligands. In our research, new platinum complexes were synthesized with α-glyoximes, such as [Pt(diethyl-glyoxH)2(amine)2], where glyoxH = mono deprotonated glyoxime, amine = imidazole, 2-amino-pyrimidine or 3-hydroxy-aniline, and with Schiff bases, such as [Pt(3-heptanone)2(en)], [Pt(3-heptanone)2(1,2-pn)], [Pt(3-heptanone)2(1,3-pn)] (en = ethylenediamine, pn = propylenediamine). The Schiff bases were obtained with the condensation reaction between 3-heptanone and the corresponding diamines. The molecular structure of our products has been investigated by IR, UV–VIS and NMR spectroscopy, MS, thermoanalytical measurements (TG-DTG-DTA), and powder XRD. The biological activity study of compounds revealed their possible application in medical point of view since some of them proved to act as antibacterial agents and potential anticancer drugs. On the other hand, some members of the family of complexes can play catalytic role in organic chemistry transformations.

Item Type: Article
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2018
Volume: 24
ISBN: 978-963-306-623-2
Page Range: pp. 26-30
Uncontrolled Keywords: Szerves kémia, Biotechnológia
Additional Information: Bibliogr.: 30. p. ; összefoglalás angol nyelven
Date Deposited: 2019. Jan. 03. 12:54
Last Modified: 2019. Jan. 03. 12:54
URI: http://acta.bibl.u-szeged.hu/id/eprint/56271

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