Determination of valine and leucine isomers in peptaibols

Endre, Gábor and Marik, Tamás and Kredics, László and Varga, Mónika and Vágvölgyi, Csaba and Szekeres, András: Determination of valine and leucine isomers in peptaibols. Proceedings of the International Symposium on Analytical and Environmental Problems, (24). pp. 283-285. (2018)

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Abstract

Peptaibols are oligomers, containing non-proteogenic amino acids. Some of them are considered as antifungal and antibiotic agents, therefore the elucidation of their structure is important. There have been a lot of efforts determining their amino acid sequences via mass spectrometry, but isobaric components cannot be determined using this technique. In this work, a HPLC method development was carried out for the determination of leucine, isoleucine, valine and isovaline in one chromatographic run. Furthermore, a chiral separation of the optical isomers of these compounds has been also solved.

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