Identification of the main metabolites of three synthetic cannabinoids using LC-MS/MS technique

Körmöczi, Tímea and Sija, Éva and Berkecz, Róbert: Identification of the main metabolites of three synthetic cannabinoids using LC-MS/MS technique. In: Proceedings of the International Symposium on Analytical and Environmental Problems, (24). pp. 316-319. (2018)

[img]
Preview
Cikk, tanulmány, mű
proceedings_of_isaep_2018_316-319.pdf

Download (910kB) | Preview

Abstract

The consumption of designer drugs today is a serious problem, especially among young people involvement. ‘Herbal mixtures’ containing synthetic cannabinoids (SCs) that mimic the effect of marijuana and there are easily available via the Internet. For analysis of urine samples, knowledge of the main metabolites is necessary as the mother compounds are usually not found in urine after using, due to their fast metabolism. The aims of this study were the in vitro identification of metabolites of ADB-FUBINACA, 5F-MDMB-PICA and CUMYL-PEGACLONE and to determine which analytical targets are excreted into urine. Metabolites identified after incubation of SCs with pooled human liver microsomes (HLM). The authentic urine samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for investigation of the major in vivo metabolites. The main metabolites were the mono-hydroxylation of ADB-FUBINACA and CUMYL-PEGACLONE in positive urine specimens. We didn’t have positive sample of 5F-MDMB-PICA.

Item Type: Article
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2018
Volume: 24
ISBN: 978-963-306-623-2
Page Range: pp. 316-319
Uncontrolled Keywords: Növénykémia, Analitikai kémia
Additional Information: Bibliogr.: 319. p. ; összefoglalás angol nyelven
Date Deposited: 2019. Jan. 08. 08:31
Last Modified: 2019. Jan. 08. 08:31
URI: http://acta.bibl.u-szeged.hu/id/eprint/56359

Actions (login required)

View Item View Item