Non-antibiotic pharmaceutical agents as antibiotic adjuvants

Gajdács, Márió: Non-antibiotic pharmaceutical agents as antibiotic adjuvants. In: Acta biologica Szegediensis, (64) 1. pp. 17-24. (2020)

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Abstract

The emergence of multidrug-resistant bacteria is a global public health issue, which severely hinders clinicians in providing patients with adequate antimicrobial treatment regimens. The strategy of drug repurposing is an emerging strategy in antimicrobial chemotherapy, during which new pharmacological uses are identified for drugs already approved. The aim of our present study was to assess the adjuvant properties of several existing and widely-used pharmacological agents against bacteria in combination with reference antibiotics. Staphylococcus aureus ATCC 25923, S. epidermidis ATCC 12228, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603 were selected for our experiments. The minimum inhibitory concentrations (MICs) of the tested compounds were determined using the broth microdilution method, while a MIC reduction assay was performed to ascertain the effect of the tested compounds on the MICs of standard antibiotics (ciprofl oxacin and gentamicin). Eight tested compounds (namely atorvastatin, celecoxib, clotrimazole, diclofenac-epolamine, ivermectin, lidocaine, mebendazole and terbinafine) showed antibacterial activity on the tested bacterial strains and several agents presented with various degrees of adjuvant (MIC-reducing) properties. Further experiments involving the screening of additional pharmaceutical compounds for their secondary antibacterial and adjuvant properties are warranted.

Item Type: Article
Journal or Publication Title: Acta biologica Szegediensis
Date: 2020
Volume: 64
Number: 1
ISSN: 1588-385X
Page Range: pp. 17-24
Publisher: University of Szeged
Place of Publication: Szeged
Related URLs: http://acta.bibl.u-szeged.hu/71095/
DOI: https://doi.org/10.14232/abs.2020.1.17-24
Uncontrolled Keywords: Gyógyszertan
Additional Information: Bibliogr.: p. 22-23. ; összefoglalás angol nyelven
Subjects: 03. Medical and health sciences
03. Medical and health sciences > 03.01. Basic medicine
03. Medical and health sciences > 03.01. Basic medicine > 03.01.06. Pharmacology and pharmacy
Date Deposited: 2020. Dec. 07. 13:13
Last Modified: 2021. Jul. 12. 11:38
URI: http://acta.bibl.u-szeged.hu/id/eprint/70954

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