Lipid biomarker-based verification of TB infection in mother’s and daughter’s mummified human remains (Vác Mummy Collection, 18th century, CE, Hungary)

Váradi Orsolya A. and Szikossy Ildikó and Spekker Olga and Rakk Dávid and Terhes Gabriella and Urbán Edit and Berthon William and Pap Ildikó and Maixner Frank and Zink Albert and Vágvölgyi Csaba and Donoghue Helen D. and Minnikin David E. and Pálfi György and Szekeres András: Lipid biomarker-based verification of TB infection in mother’s and daughter’s mummified human remains (Vác Mummy Collection, 18th century, CE, Hungary). In: Acta biologica Szegediensis, (64) 2. pp. 99-109. (2020)

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Abstract

The perpetual burden of tuberculosis (TB) keeps drawing the focus of research on this disease. Among other risk factors (e.g., poor living conditions, malnutrition, smoking, HIV infection, etc.), being in close contact with a TB infected person requires special attention. For a better understanding of the disease, paleopathological investigations concerning TB have been carried out with various techniques for a long a time; nevertheless, analysis of incidence among family members is hardly possible in past populations. An exceptional group of naturally mummifi ed individuals, the collection of the Vác mummies (Hungary, 18th century CE), is known about the large TB incidence rate, which has been revealed by aDNA analysis. Besides the high rate of TB infection, another interesting aspect of the collection is that in some cases, the family connections could be reconstructed. In this paper, we present the mycocerosic acid profi les gained by HPLC-HESI-MS measurements of two Vác mummies, who were mother and daughter according to the personal records. Earlier metagenomic analysis already revealed mixed M. tuberculosis infection with the same bacterial strains in both individuals; moreover, the same bacterial strains were recorded in both cases.

Item Type: Article
Journal or Publication Title: Acta biologica Szegediensis
Date: 2020
Volume: 64
Number: 2
ISSN: 1588-4082
Page Range: pp. 99-109
Language: English
Related URLs: http://acta.bibl.u-szeged.hu/73049/
DOI: 10.14232/abs.2020.2.99-109
Uncontrolled Keywords: Múmia, Embertan, Paleopatológia, Tuberkulózis
Additional Information: Bibliogr.: p. 105-109. ; ill. ; összefoglalás angol nyelven
Subjects: 03. Medical and health sciences
03. Medical and health sciences > 03.03. Health sciences
03. Medical and health sciences > 03.03. Health sciences > 03.03.07. Public and environmental health
03. Medical and health sciences > 03.03. Health sciences > 03.03.07. Public and environmental health > 03.03.07.01. Public health
03. Medical and health sciences > 03.03. Health sciences > 03.03.07. Public and environmental health > 03.03.07.01. Public health > 03.03.07.01.38. Tuberculosis
03. Medical and health sciences > 03.05. Other medical sciences
03. Medical and health sciences > 03.05. Other medical sciences > 03.05.01. Other medical sciences
Date Deposited: 2021. Jul. 15. 13:57
Last Modified: 2021. Jul. 15. 13:57
URI: http://acta.bibl.u-szeged.hu/id/eprint/73060

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