Traj Péter and Abdolkhaliq Ali Hazhmat and Németh Anett and Dajcs Sámuel Trisztán and Zupkó István and Mernyák Erzsébet: Transition metal-catalyzed synthesis of 13α-estrone derivatives with potential anticancer properties.
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Abstract
Synthesis of 3-(N,N-dimethylcarbamoyl)-13α-estrone and its 17-deoxy counterpart has been carried out. The dimethylcarbamoyl directing group enabled the regioselective ortho arylation of the steroidal starting compounds. The microwave-assisted, palladium-catalyzed phenylations led to 2-substituted 13α-estrones in a one-pot, tandem process. The Suzuki-Miyaura cross coupling reactions of the carbamates with phenylboronic acid resulted in 3-phenyl-3-deoxy13α-estrone. Certain newly synthesized compounds displayed potent antiproliferative action against human reproductive cancer cell lines of gynecological origin.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2020 |
| Volume: | 26 |
| ISBN: | 978-963-306-771-0 |
| Page Range: | pp. 338-341 |
| Language: | English |
| Event Title: | International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged) |
| Related URLs: | http://acta.bibl.u-szeged.hu/73792/ |
| Uncontrolled Keywords: | Gyógyszerkémia, Analitikai kémia |
| Additional Information: | Bibliogr.: 341. p. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences |
| Date Deposited: | 2021. Nov. 18. 13:02 |
| Last Modified: | 2022. Aug. 08. 15:39 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/74032 |
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