Vasiljević Bojana and Prekodravac Jovana and Jovanovic Dragana: Synthesis of bile acid amines via microwave irradiation.
Preview |
Cikk, tanulmány, mű
proceedings_of_isaep_2020_344-348.pdf Download (426kB) | Preview |
Abstract
Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, formylated bile acid have been proved as excellent starting material for the synthesis of bile acid`s N-morpholino amine. Microwave-assisted reactions of formylation in the absence of catalyst, selective deformylation, as well as further oxidation with N-bromosuccinimide gained 3-oxo derivatives of deoxycholic acid acid in high yield. Compared to the conventional protocol a remarkable reduction in overall processing time from hours to a few minutes was achieved.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2020 |
| Volume: | 26 |
| ISBN: | 978-963-306-771-0 |
| Page Range: | pp. 344-348 |
| Language: | English |
| Event Title: | International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged) |
| Related URLs: | http://acta.bibl.u-szeged.hu/73792/ |
| Uncontrolled Keywords: | Kémia |
| Additional Information: | Bibliogr.: 348. p. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences |
| Date Deposited: | 2021. Nov. 18. 13:24 |
| Last Modified: | 2022. Aug. 08. 15:39 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/74034 |
Actions (login required)
 |
View Item |
