Synthesis of bile acid amines via microwave irradiation

Vasiljević Bojana and Prekodravac Jovana and Jovanovic Dragana: Synthesis of bile acid amines via microwave irradiation.

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Abstract

Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, formylated bile acid have been proved as excellent starting material for the synthesis of bile acid`s N-morpholino amine. Microwave-assisted reactions of formylation in the absence of catalyst, selective deformylation, as well as further oxidation with N-bromosuccinimide gained 3-oxo derivatives of deoxycholic acid acid in high yield. Compared to the conventional protocol a remarkable reduction in overall processing time from hours to a few minutes was achieved.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2020
Volume: 26
ISBN: 978-963-306-771-0
Page Range: pp. 344-348
Language: English
Event Title: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Related URLs: http://acta.bibl.u-szeged.hu/73792/
Uncontrolled Keywords: Kémia
Additional Information: Bibliogr.: 348. p. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2021. Nov. 18. 13:24
Last Modified: 2022. Aug. 08. 15:39
URI: http://acta.bibl.u-szeged.hu/id/eprint/74034

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