Vasiljević Bojana and Prekodravac Jovana and Jovanovic Dragana: Synthesis of bile acid amines via microwave irradiation.
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Abstract
Herein, we present microwave-assisted reductive amination of oxo derivative of deoxycholic acid with morpholine in the presence of sodium-cyanoborohydride. These chemical transformation produces a majority of the 3β-amino isomer 5 as a new compound after five minutes of irradiation. In addition, formylated bile acid have been proved as excellent starting material for the synthesis of bile acid`s N-morpholino amine. Microwave-assisted reactions of formylation in the absence of catalyst, selective deformylation, as well as further oxidation with N-bromosuccinimide gained 3-oxo derivatives of deoxycholic acid acid in high yield. Compared to the conventional protocol a remarkable reduction in overall processing time from hours to a few minutes was achieved.
Item Type: | Conference or Workshop Item |
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Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
Date: | 2020 |
Volume: | 26 |
ISBN: | 978-963-306-771-0 |
Page Range: | pp. 344-348 |
Language: | English |
Event Title: | International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged) |
Related URLs: | http://acta.bibl.u-szeged.hu/73792/ |
Uncontrolled Keywords: | Kémia |
Additional Information: | Bibliogr.: 348. p. ; összefoglalás angol nyelven |
Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences |
Date Deposited: | 2021. Nov. 18. 13:24 |
Last Modified: | 2022. Aug. 08. 15:39 |
URI: | http://acta.bibl.u-szeged.hu/id/eprint/74034 |
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