Investigation of the transformation of 5-fluorouracil cytostatics by UV and VUV photolysis

Dercze Dávid and Farkas Luca and Alapi Tünde: Investigation of the transformation of 5-fluorouracil cytostatics by UV and VUV photolysis.

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Abstract

In this work, UV (254 nm), UV/VUV185 nm, and VUV172 nm photolysis of 5-fluorouracil (5- FLU), a cytostatic drug were investigated. For the water treatments three type of lightsources were applied: a low-pressure mercury vapour lamps emitting only 254 nm UV light, an other low-pressure mercury vapour lamps emitting both 254 nm UV and 185 nm VUV light, and a Xe excimer light source emitting 172 nm VUV photons. In parallel, with the transformation of 5-FLU, H2O2 formation was detected and measured. During UV/VUV185 nm photolysis, the formation of H2O2 follows a maximum curve, while in the case of UV photolysis, it shows a saturation curve. Its concentration reached higher value in the case of UV/VUV185 nm than in UV radiation. To enhance the efficiency of the reactors, we used air, O2 and N2 gases and assessed their effect to the photolysis of 5-FLU to see wich parameters are the most suitable for transforming it.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2020
Volume: 26
ISBN: 978-963-306-771-0
Page Range: pp. 379-383
Language: English
Event Title: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Related URLs: http://acta.bibl.u-szeged.hu/73792/
Uncontrolled Keywords: Analitikai kémia
Additional Information: Bibliogr.: 383. p. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2021. Nov. 18. 15:23
Last Modified: 2022. Aug. 08. 15:39
URI: http://acta.bibl.u-szeged.hu/id/eprint/74043

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