Novel iron complexes with glyoximes, schiff bases and boric acid derivatives : synthesis, physico-chemical analysis and biological study

Várhelyi Csaba and Kuzmann Ernő and Homonnay Zoltán and Szalay Roland and Pokol György and Goga Firuţa and Huszthy Péter and Papp Judit and Simon-Várhelyi Melinda and Tötös Róbert and Avram Alexandra: Novel iron complexes with glyoximes, schiff bases and boric acid derivatives : synthesis, physico-chemical analysis and biological study.

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Abstract

Iron(II) clathrochelate complexes obtained with glyoximes are macrobicyclic ligand systems, which completely encapsulate the metal ion, and are formed under mild conditions with high yields [1]. In particular, the riblike-functionalized clatrochelates both with the inherent and with the terminal closo-borate substituents synthesized recently have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [2]. In our research work new iron(II) complexes were synthesized with -glyoximes, boric acid derivatives, amines, Schiff bases, such as [Fe(Me-Pr-Glyox)3(BO–Et)2], [Fe(Et-BuGlyox)3(BO–R)2] (R = methyl, propyl, butyl), [Fe(phenyl-Me-GlyoxH)2(amine)2], [Fe(Et-BuGlyoxH)2(amine)2], [Fe(2-heptanone)2(en)(amine)2], where GlyoxH, Glyox = mono- or bideprotonated glyoxime, en = ethylenediamine and the used amines: dibutylamine, 3-picoline, 4-aminopyridine, 6-amino-3-picoline, 3-amino-1-propanol, imidazole, 2-aminopyrimidine, 3- methylpiperidine, 3-amino-1H-1,2,4-triazole. For preparation ironII -sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines and the other complexing agents were added. The mixture so obtained was refluxed under inert atmosphere. The molecular structures of our products were studied by IR, Mössbauer and UV–VIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). The biological activity, like antimicrobial effect, was studied for a few bacteria.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2021
Volume: 27
ISBN: 978-963-306-835-9
Page Range: pp. 61-66
Language: English
Publisher: University of Szeged
Place of Publication: Szeged
Event Title: International Symposium on Analytical and Environmental Problems (27.) (2021) (Szeged)
Related URLs: http://acta.bibl.u-szeged.hu/75798/
Uncontrolled Keywords: Fizikai kémia, Analitikai kémia
Additional Information: Bibliogr.: p. 65-66. ; ill. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2022. May. 26. 12:20
Last Modified: 2022. Aug. 08. 15:40
URI: http://acta.bibl.u-szeged.hu/id/eprint/75924

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