Novel iron complexes with glyoximes, schiff bases and boric acid derivatives : synthesis, physico-chemical analysis and biological study

Várhelyi Csaba; Kuzmann Ernő; Homonnay Zoltán; Szalay Roland; Pokol György; Goga Firuţa; Huszthy Péter; Papp Judit; Simon-Várhelyi Melinda; Tötös Róbert; Avram Alexandra: Novel iron complexes with glyoximes, schiff bases and boric acid derivatives : synthesis, physico-chemical analysis and biological study.

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Absztrakt (kivonat)

Iron(II) clathrochelate complexes obtained with glyoximes are macrobicyclic ligand systems, which completely encapsulate the metal ion, and are formed under mild conditions with high yields [1]. In particular, the riblike-functionalized clatrochelates both with the inherent and with the terminal closo-borate substituents synthesized recently have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [2]. In our research work new iron(II) complexes were synthesized with -glyoximes, boric acid derivatives, amines, Schiff bases, such as [Fe(Me-Pr-Glyox)3(BO–Et)2], [Fe(Et-BuGlyox)3(BO–R)2] (R = methyl, propyl, butyl), [Fe(phenyl-Me-GlyoxH)2(amine)2], [Fe(Et-BuGlyoxH)2(amine)2], [Fe(2-heptanone)2(en)(amine)2], where GlyoxH, Glyox = mono- or bideprotonated glyoxime, en = ethylenediamine and the used amines: dibutylamine, 3-picoline, 4-aminopyridine, 6-amino-3-picoline, 3-amino-1-propanol, imidazole, 2-aminopyrimidine, 3- methylpiperidine, 3-amino-1H-1,2,4-triazole. For preparation ironII -sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines and the other complexing agents were added. The mixture so obtained was refluxed under inert atmosphere. The molecular structures of our products were studied by IR, Mössbauer and UV–VIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). The biological activity, like antimicrobial effect, was studied for a few bacteria.

Mű típusa:	Konferencia vagy workshop anyag
Befoglaló folyóirat/kiadvány címe:	Proceedings of the International Symposium on Analytical and Environmental Problems
Dátum:	2021
Kötet:	27
ISBN:	978-963-306-835-9
Oldalak:	pp. 61-66
Nyelv:	angol
Kiadó:	University of Szeged
Kiadás helye:	Szeged
Konferencia neve:	International Symposium on Analytical and Environmental Problems (27.) (2021) (Szeged)
Befoglaló mű URL:	http://acta.bibl.u-szeged.hu/75798/
Kulcsszavak:	Fizikai kémia, Analitikai kémia
Megjegyzések:	Bibliogr.: p. 65-66. ; ill. ; összefoglalás angol nyelven
Szakterület:	01. Természettudományok 01. Természettudományok > 01.04. Kémiai tudományok
Feltöltés dátuma:	2022. máj. 26. 12:20
Utolsó módosítás:	2022. aug. 08. 15:40
URI:	http://acta.bibl.u-szeged.hu/id/eprint/75924

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