Vacuum-ultraviolet photolysis of non-steroidal anti-inflammatory drugs

Arany Eszter and Cerrone Sandra and Szabó Rita Katalin and Alapi Tünde and Schrantz Krisztina and Dombi András: Vacuum-ultraviolet photolysis of non-steroidal anti-inflammatory drugs.

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Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) ibuprofen, ketoprofen, diclofenac and naproxen are detected even in natural waters. Their degradation was achieved through the generation of reactive oxygen containing species (ROS, such as *OH, 1102* and •O2’) by using a xenon excimer lamp (Xmax. = 172 ± 14 nm). The effect of the initial drug concentration, dissolved molecular oxygen, methanol as *OH scavenger and the effect of these pharmaceuticals on each other were investigated. According to the results, not only the reactions based on *OH, but the reactions with other ROS and excited water molecules should also be taken under consideration for the interpretation of the transformation of the four investigated NSAIDs.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2012
Volume: 17
ISBN: 978-963-315-066-5
Page Range: pp. 64-67
Language: English
Publisher: SZAB
Place of Publication: Szeged
Event Title: International Symposium on Analytical and Environmental Problems (17.) (2011) (Szeged)
Event Type: Conference
Event Location: Szeged
Event Dates: 2011. szeptember 19.
Related URLs: http://acta.bibl.u-szeged.hu/76381/
Uncontrolled Keywords: Gyógyszerkémia, Analitikai kémia
Additional Information: Bibliogr.: 67. p. ; ill. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2022. Aug. 09. 10:34
Last Modified: 2022. Aug. 22. 10:23
URI: http://acta.bibl.u-szeged.hu/id/eprint/76391

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