In vivo and in vitro tests for the detection of biochemical and ecotoxicological effects of the herbicide active ingredient glyphosate

Gémes Borbála and Klátyik Szandra and Oláh Marianna and Takács Eszter and Krifaton Csilla and Székács András: In vivo and in vitro tests for the detection of biochemical and ecotoxicological effects of the herbicide active ingredient glyphosate.

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Abstract

Aquatic organisms are outstandingly exposed to water contaminants because of their unavoidable contact with xenobiotics, thus their exposure needs to be routinely monitored. Due to its extensive use, the herbicidal agrochemical active ingredient glyphosate realizes massive exposure, its toxic effects alone and in formulations were evaluated in different in vivo aquatic ecotoxicological tests on various algae species, freshwater biofilm communities, Daphnia magna, and Danio rerio, furthermore the possible cytotoxic, genotoxic, and hormonemodulating effects were evaluated in vitro on different cell lines and test organisms. Significant differences were detected in the individual and combined toxicity of glyphosate and its coformulants presented in the formulations, therefore various additives cannot be classified as unequivocally inactive components. The result of the in vivo testing proved higher toxicity for the formulating agent and the formulation compared to the individual effect of glyphosate, and significant differences in the sensitivity of test species, and the effects on the sexual development of fish were also observed. The performed in vitro assays on cell lines demonstrated the potential cytotoxic and genotoxic effects of glyphosate and its formulations, and some of the effects are the result of the individual toxicity of glyphosate.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2022
Volume: 28
ISBN: 978-963-306-904-2
Page Range: pp. 152-156
Language: English
Place of Publication: Szeged
Event Title: 28th International Symposium on Analytical and Environmental Problems
Event Type: Conference
Event Location: Szeged
Event Dates: 2022. november 14-15.
Related URLs: https://acta.bibl.u-szeged.hu/78308/
Uncontrolled Keywords: Biokémia
Additional Information: Bibliogr.: 156. p. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2023. Mar. 20. 13:10
Last Modified: 2023. Mar. 20. 13:10
URI: http://acta.bibl.u-szeged.hu/id/eprint/78492

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