Synthesis of red-emitting fluorophores

Hlogyik Tamás and Mernyák Erzsébet: Synthesis of red-emitting fluorophores.

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Understanding the mechanism of action of biologically active compounds is of great interest in medicine, including cancer research. Chemical labeling of molecules, i.e. making them "visible" under the right conditions, is a widespread and intensively researched field of science. The fluorescent labeling of compounds offers several advantages over other methods. It might be considered as an environmentally friendly alternative to radioisotope labeling. It is highly important that fluorophores used in biomedical applications meet certain criteria, including high photostability, good cell permeability and stability under physiological conditions. However, the accessibility of the fluorophores is often limited owing to their high price and complex synthetic strategies. Here we synthesized aza-BODIPY fluorophores, which are red-emitting altervatives to BODIPY derivatives. The syntheses were carried out considering the principles of green chemistry. One-pot and/or microwave-assisted syntheses were performed in order to minimize the number of reaction steps and time and use of solvents.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2022
Volume: 28
ISBN: 978-963-306-904-2
Page Range: pp. 170-173
Language: English
Place of Publication: Szeged
Event Title: 28th International Symposium on Analytical and Environmental Problems
Event Type: Conference
Event Location: Szeged
Event Dates: 2022. november 14-15.
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Uncontrolled Keywords: Kémia
Additional Information: Bibliogr.: 173. p. ; ill. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2023. Mar. 22. 07:58
Last Modified: 2023. Mar. 22. 07:58

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