Žabčić Martina and Nikolić Nataša and Mijin Dušan and Kačarević Popović Zorica and Porobić Slavica and Tadić Julijana: Synthesis and physicochemical evaluation of new chitosan-based scaffolds for potential application in biomedicine.
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Abstract
Chitosan is a natural polymer obtained by deacetylation of chitin. Due to its biocompatibility and biodegradability, chitosan-based materials have a wide range of biomedical applications in wound dressings, drug delivery systems, and tissue engineering. Also, studies in the fields of organic and medicinal chemistry show that compounds based on the pyridone core exhibit biological properties including antimicrobial, anticancer, and antioxidant activity, and moreover have the potential as new therapeutics for various diseases from cardiovascular to antitumor therapy. In this study, new biomaterials were synthesized using low and medium molecular weight chitosan polymers and pyridone-based hydrazone. In order to improve stability of the obtained scaffolds, scaffolds’ neutralization was carried out using ethanol and sodium hydroxide solutions. The interactions established between chitosan polymer chains and pyridone compound were analyzed by FT-IR spectroscopy. Swelling and degradation tests of the materials were studied in water and PBS, and the influence of different polymer molecular weights on the scaffolds’ properties was evaluated. The results indicated that synthetized scaffolds have a high potential for biomedical use.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2022 |
| Volume: | 28 |
| ISBN: | 978-963-306-904-2 |
| Page Range: | pp. 345-349 |
| Language: | English |
| Place of Publication: | Szeged |
| Event Title: | 28th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2022. november 14-15. |
| Related URLs: | https://acta.bibl.u-szeged.hu/78308/ |
| Uncontrolled Keywords: | Orvosbiológia, Gyógyszerkémia |
| Additional Information: | Bibliogr.: 349. p. ; ill. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences |
| Date Deposited: | 2023. Mar. 23. 14:57 |
| Last Modified: | 2023. Mar. 23. 14:57 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/78560 |
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