Glycolipidomics of human cerebellum in development and aging by ion mobility tandem mass spectrometry

Biricioiu Roxana and Sarbu Mirela and Ica Raluca and Zamfir Alina D.: Glycolipidomics of human cerebellum in development and aging by ion mobility tandem mass spectrometry.

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Abstract

In this study ion mobility separation (IMS) mass spectrometry (MS) was for the first time introduced in human cerebellum ganglioside research. The work was focused on a comprehensive mapping and structural characterization of human cerebellar gangliosides and determination of the specific changes induced in their expression by brain development and aging. We have carried out a comparative IMS MS mapping of the native ganglioside mixtures extracted from fetal cerebellum in the second trimester of pregnancy vs. near-term fetus vs. aged cerebellum, followed by IMS CID MS/MS fragmentation analysis.

Item Type:	Conference or Workshop Item
Journal or Publication Title:	Proceedings of the International Symposium on Analytical and Environmental Problems
Date:	2023
Volume:	29
ISBN:	978-963-306-963-9
Page Range:	pp. 95-96
Language:	English
Publisher:	University of Szeged
Place of Publication:	Szeged
Event Title:	29th International Symposium on Analytical and Environmental Problems
Event Type:	Conference
Event Location:	Szeged
Event Dates:	2023. november 13-14.
Related URLs:	https://acta.bibl.u-szeged.hu/82256/
Uncontrolled Keywords:	Tömegspektrometria
Additional Information:	Bibliogr.: 96. p. ; összefoglalás angol nyelven
Subjects:	01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences
Date Deposited:	2023. Nov. 22. 09:37
Last Modified:	2023. Nov. 22. 09:37
URI:	http://acta.bibl.u-szeged.hu/id/eprint/82376

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