C18-UHPLC analysis of retention behavior of newly designed o-alkylated and rostane derivatives in ternary mixture methanol/acetonitrile/water

Karadžić Banjac Milica and Kovačević Strahinja and Anojčić Jasmina and Ajduković Jovana and Podunavac-Kuzmanović Sanja: C18-UHPLC analysis of retention behavior of newly designed o-alkylated and rostane derivatives in ternary mixture methanol/acetonitrile/water.

Cikk, tanulmány, mű proceedings_of_isaep_2023_176-180.pdf Download (348kB)

Abstract

Different new groups of steroid compounds are the center of attention in a grate number of scientific publications since the majority of compounds are being researched as anticancer drugs. One of the most important feature of potential drug is its lipophilicity. Nowadays, ultra high-performance liquid chromatography (UHPLC) is used as one of the most sophisticated techniques for determination of the retention behavior determination of different biologically active compounds. The series of 18 newly designed O-alkylated androstane derivatives was investigated in reversed phase (RP)-UHPLC system using ternary mixture methanol/acetonitrile/water. A good agreement between experimentally observed and in silico lipophilicity was noticed given that coefficient of determination of 0.8406 was achieved.

Item Type:	Conference or Workshop Item
Journal or Publication Title:	Proceedings of the International Symposium on Analytical and Environmental Problems
Date:	2023
Volume:	29
ISBN:	978-963-306-963-9
Page Range:	pp. 176-180
Language:	English
Publisher:	University of Szeged
Place of Publication:	Szeged
Event Type:	Conference
Event Location:	Szeged
Event Dates:	2023. november 13-14.
Related URLs:	https://acta.bibl.u-szeged.hu/82256/
Uncontrolled Keywords:	Gyógyszerkémia
Additional Information:	Bibliogr.: p. 179-180. ; összefoglalás angol nyelven
Subjects:	01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences 03. Medical and health sciences 03. Medical and health sciences > 03.01. Basic medicine
Date Deposited:	2023. Nov. 23. 08:26
Last Modified:	2023. Nov. 23. 08:33
URI:	http://acta.bibl.u-szeged.hu/id/eprint/82413

Actions (login required)

View Item