Kovačević Strahinja and Karadžić Banjac Milica and Anojčić Jasmina and Ajduković Jovana and Podunavac-Kuzmanović Sanja: Retention behavior of novel o-alkylated androstane 3-oximes IN RP(C18)-UHPLC system with methanol/water mobile phase.
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Abstract
The retention behavior of newly synthesized O-alkylated androstane 3-oximes has been investigated applying reversed-phase ultra-high performance liquid chromatography (RPUHPLC) with octadecyl stationary phase and methanol/water mobile phase. The set of the analyzed compounds takes into account two groups of steroidal derivatives: 17α-(pyridin-2- yl)methyl and (17E)-(pyridin-2-yl)methylidene derivatives. The retention behavior of the compounds in the applied chromatographic system was determined as logarithm of the capacity factor (logk). Afterwards, the logk values were correlated with in silico lipophilicity (logP) in order to establish the quantitative structure-retention relationship (QSRR) model and to confirm that the obtained retention parameters can be considered chromatographic (anisotropic) lipophilicity parameters. The obtained QSRR model successfully correlates the logk and logP parameters (the strong correlation has been determined). Considering the lipophilicity parameters, the analyzed compounds can be considered from moderately to highly lipophilic.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2023 |
| Volume: | 29 |
| ISBN: | 978-963-306-963-9 |
| Page Range: | pp. 187-190 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Title: | 29th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2023. november 13-14. |
| Related URLs: | https://acta.bibl.u-szeged.hu/82256/ |
| Uncontrolled Keywords: | Kémia |
| Additional Information: | Bibliogr.: 190. p. ; ill. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences |
| Date Deposited: | 2023. Nov. 23. 09:25 |
| Last Modified: | 2023. Nov. 23. 09:25 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/82416 |
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