Synthesis of Iron(II)-complexes with glyoximes and boric acid derivatives, and their physical-chemical and biological studies

Várhelyi Csaba and Kuzmann Ernő and Homonnay Zoltán and Szalay Roland and Madarász János and Mereu Raluca-Anca and Papp Judit and Simon-Várhelyi Melinda and Tötös Róbert and Mihály Judith: Synthesis of Iron(II)-complexes with glyoximes and boric acid derivatives, and their physical-chemical and biological studies.

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Abstract

Iron(II) complexes obtained with glyoximes are macrobicyclic ligand systems, which are formed under mild conditions with high yields [1]. The biological activity of these compounds is of particular importance. Some boric acid derivatives have been proposed as new radiopharmaceuticals for boron neutron capture therapy of cancer [2]. In our research work new iron(II) complexes were synthesized with -dioximes, amines, boric acid derivatives, such as [Fe(Ph-Me-DioxH)2L2], [Fe(Me-i-Pr-DioxH)2L2] [Fe(Ph-Me-Diox)3(BO–R)2], [Fe(Bu-Me-Diox)3(BO–R)2], [Fe(i-Pr-Me-Diox)3(BO–R)2], where DioxH, Diox = mono- or bi-deprotonated dioxime, L = 1-naphthylamine, 2-methylimidazole, 2-amino-4-methyl-pyridine, lepidine, m-toluidine, dicyclohexylamine, 2-amino-5- picoline, R = H, methyl, ethyl, isopropyl, n-propyl, isobutyl, n-butyl. For preparation ironII sulfate was dissolved in water and mixed with alcoholic solution of the glyoxime, then the corresponding amines or the other complexing agents were added. The mixture so obtained was refluxed under an inert atmosphere. The molecular structures of our products were studied using a range of techniques, including IR, Raman, Mössbauer and UV–VIS spectroscopies, mass spectrometry (MS) and thermoanalytical measurements (TG-DTG-DTA). In addition, their biological activity, including the antimicrobial effect against certain bacterial strains, was also investigated.

Item Type: Conference or Workshop Item
Journal or Publication Title: Proceedings of the International Symposium on Analytical and Environmental Problems
Date: 2024
Volume: 30
ISBN: 978-963-688-009-5
Page Range: pp. 32-36
Language: English
Publisher: University of Szeged
Place of Publication: Szeged
Event Title: 30th International Symposium on Analytical and Environmental Problems
Event Type: Conference
Event Location: Szeged
Event Dates: 2024. október 7-8.
Related URLs: https://acta.bibl.u-szeged.hu/85607/
Uncontrolled Keywords: Szerves kémia, Anyagkémia, Vas - fizikai-kémiai tulajdonságok
Additional Information: Bibliogr.: 36. p. ; ill. ; összefoglalás angol nyelven
Subjects: 01. Natural sciences
01. Natural sciences > 01.04. Chemical sciences
Date Deposited: 2024. Nov. 20. 10:24
Last Modified: 2024. Nov. 20. 11:03
URI: http://acta.bibl.u-szeged.hu/id/eprint/85653

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