Biricioiu Roxana and Sarbu Mirela and Ica Raluca and Vukelić Željka and Clemmer David E. and Zamfir Alina D.: Gangliosidomics of cephalic disorders by ion mobility mass spectrometry.
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Abstract
In this study we report on the determination of anencephaly gangliosidome by ion mobility separation (IMS) mass spectrometry (MS), introduced here for the first time in the research of cephalic disorders. Ganglioside (GG) extracts from residual brains of anencephalic fetuses in various gestational weeks were comparatively profiled by IMS MS, structurally analyzed by IMS tandem MS (MS/MS), and, finally, assessed against a native ganglioside mixture from normal fetal brain. The comparative assay disclosed variations in GG expression with fetal age and a correlation of the pattern with the developmental stage. In contrast to the normal fetal brain, the neural tissue in anencephaly was found to contain an elevated number of polysialogangliosides and a lower expression of O-Ac- and GalNAc-modified glycoforms.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2024 |
| Volume: | 30 |
| ISBN: | 978-963-688-009-5 |
| Page Range: | pp. 82-84 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Title: | 30th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2024. október 7-8. |
| Related URLs: | https://acta.bibl.u-szeged.hu/85607/ |
| Uncontrolled Keywords: | Ideggyógyászat - kutatás, Ionmobilitás tömegspektrometria, Elektrokémia, Biomarker-elemzés, Lipidszerkezetek |
| Additional Information: | Bibliogr.: 84. p. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences 03. Medical and health sciences 03. Medical and health sciences > 03.02. Clinical medicine |
| Date Deposited: | 2024. Nov. 21. 09:00 |
| Last Modified: | 2024. Nov. 21. 09:00 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/85672 |
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