Sarbu Mirela and Vukelić Željka and Clemmer David E. and Zamfir Alina D.: Discovery of ganglioside biomarkers in brain metastasis of lung adenocarcinoma by travelling-wave ion mobility separation mass spectrometry.
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Abstract
High performance travelling-wave ion mobility separation mass spectrometry (TWIMS MS) was thoroughly optimized to allow the discovery of brain metastasis of lung adenocarcinoma (BMLA)-specific structures and the assessment of their roles as tumor markers or possible associated antigens. Ganglioside (GG) separation by TWIMS according to the charge state, carbohydrate chain length, degree of sialylation and ceramide composition, led to the identification of no less than 151 distinct components. The detected GGs and asialo-GGs were found characterized by a high heterogeneity in their ceramide and glycan compositions, encompassing up five Neu5Ac residues. The tumor was found dominated by GM3 and GT1 forms, with a particular incidence of C26 fatty acids in the ceramide.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2024 |
| Volume: | 30 |
| ISBN: | 978-963-688-009-5 |
| Page Range: | pp. 200-201 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Title: | 30th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2024. október 7-8. |
| Related URLs: | https://acta.bibl.u-szeged.hu/85607/ |
| Uncontrolled Keywords: | Tömegspektrometriás analízis, Rákbetegség - diagnosztika - módszer, Molekuláris biológia, Biokémia |
| Additional Information: | Bibliogr.: 201. p. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences 01. Natural sciences > 01.06. Biological sciences 03. Medical and health sciences 03. Medical and health sciences > 03.02. Clinical medicine |
| Date Deposited: | 2024. Nov. 22. 13:00 |
| Last Modified: | 2024. Nov. 22. 13:00 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/85709 |
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