Molnár Zsolt and Kiss Péter Sándor and Mózes Miklós and Radács Marianna and Hausinger Péter and Sepp Krisztián and Gálfi Márta: A neurohypophysis and adenohypophysis model for the investigation of deponated chemical environmental loads.
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Abstract
Persistent organic pollutants, chemicals with high chemical stability and low degradability, widely used in industry and/or agriculture. A heterogeneous group of these compounds include chlorobenzenes (ClB), which are deposited in the lipophilic phases of living organisms and induce dose-dependent toxic effects in the cells of affected tissues. The aim of this study was to monitor the effects of different doses of ClB treatments on changes in energy transfer (Mg2+- ATPase) and protein production of neurohypophysis and adenohypophysis. Male Wistar rats were treated with ClB (1:1 mixture of hexachlorobenzene and 1,2,4-trichlorobenzene) in a dose of 1.0 and 10.0 µg /b.w. kg through a gastric tube. Rats were exposed to ClB for 30, 60, and 90 days. The results showed that ClB exposures significantly increased energy transfer and protein production in cell cultures.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2024 |
| Volume: | 30 |
| ISBN: | 978-963-688-009-5 |
| Page Range: | pp. 341-345 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Title: | 30th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2024. október 7-8. |
| Related URLs: | https://acta.bibl.u-szeged.hu/85607/ |
| Uncontrolled Keywords: | Biokémia, Környezetkémia, Toxikológia, Molekuláris biológia |
| Additional Information: | Bibliogr.: 345. p. ; ill. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences 01. Natural sciences > 01.06. Biological sciences |
| Date Deposited: | 2024. Nov. 27. 09:27 |
| Last Modified: | 2024. Nov. 27. 09:27 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/85755 |
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