Zeini Hiba and Mernyák Erzsébet and Vágvölgyi Máté and Girst Gábor and Berkecz Róbert and Hunyadi Attila: Squalenoylated nanoparticle prodrugs.
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Abstract
Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly synthesized compounds were purified by HPLC to over 95% and their structures were confirmed by NMR and HRMS. The squalenoylated compounds will be used for the synthesis of self-assembling nanoparticles, which will be subjected to investigation of their antiproliferative activity. This approach may enhance the stability and biological activity of the lead compound, advancing its therapeutic potential.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2024 |
| Volume: | 30 |
| ISBN: | 978-963-688-009-5 |
| Page Range: | pp. 386-387 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Title: | 30th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2024. október 7-8. |
| Related URLs: | https://acta.bibl.u-szeged.hu/85607/ |
| Uncontrolled Keywords: | Biokémia, Nanotechnológia, Gyógyszerkémia |
| Additional Information: | Bibliogr.: 387. p. ; ill. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.04. Chemical sciences |
| Date Deposited: | 2024. Nov. 27. 12:16 |
| Last Modified: | 2024. Nov. 27. 12:16 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/85768 |
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