Tran Thi Phuong Nhung; Le Pham Tan Quoc: Protective effects of black shallot extract against acetaminophen-induced nephrotoxicity in mice. In: Acta biologica Szegediensis, (67) 2. pp. 177-185. (2023)
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Acetaminophen (APAP), widely recognized for its analgesic and antipyretic properties, poses a risk of renal toxicity in cases of overdose. Traditional herbal remedies are frequently employed to counteract drug-induced renal damage. This study focuses on black shallot, an innovative food product derived from Allium ascalonicum, a plant highly valued in traditional Vietnamese medicine. The aim is to explore the protective effects of black shallot ethanol extract (BSEE) against APAP-induced nephrotoxicity in mice. BSEE was orally administered at various doses (200, 250, and 300 mg/kg) in combination with APAP (3 g/kg). N-acetylcysteine (NAC) (50 mg/kg) served as the reference drug, while saline (10 mL/kg) functioned as the negative control. Evaluations encompassed renal histology, serum and urine renal function tests, antioxidant enzyme concentrations (SOD, CAT, and GPx), lipid peroxidation, and anti-inflammatory cytokines (TNF-α, IL-1β, and IL-6). The findings indicated significant alterations in total protein, albumin, BUN, and serum/urine CRE concentrations (P < 0.05), coupled with a decrease in malondialdehyde (MDA) levels (P < 0.05) and inflammatory cytokines TNF-α, IL-1β, and IL-6 (P < 0.05). Remarkable elevations were observed in antioxidant enzyme concentrations, including renal catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) (P < 0.05). The macroscopic and microscopic structures of the kidneys exhibited significant improvement. Consequently, BSEE effectively safeguards against APAP-induced renal damage, as evidenced by enhanced renal structure, reduced inflammation, and biochemical modulation, highlighting its potential therapeutic application in preventing APAP-induced nephrotoxicity.
| Mű típusa: | Cikk, tanulmány, mű |
|---|---|
| Befoglaló folyóirat/kiadvány címe: | Acta biologica Szegediensis |
| Dátum: | 2023 |
| Kötet: | 67 |
| Szám: | 2 |
| ISSN: | 1588-4082 |
| Oldalak: | pp. 177-185 |
| Nyelv: | angol |
| Kiadó: | University of Szeged |
| Kiadás helye: | Szeged |
| Befoglaló mű URL: | https://acta.bibl.u-szeged.hu/86900/ |
| DOI: | 10.14232/abs.2023.2.177-185 |
| Kulcsszavak: | Toxikológia, Veseélettan, Patofiziológia, Gyógyszerkémia |
| Megjegyzések: | Bibliogr.: p. 184-185. ; ill. ; összefoglalás angol nyelven |
| Szakterület: | 01. Természettudományok 01. Természettudományok > 01.06. Biológiai tudományok 03. Orvos- és egészségtudomány 03. Orvos- és egészségtudomány > 03.01. Általános orvostudomány |
| Feltöltés dátuma: | 2025. ápr. 15. 10:32 |
| Utolsó módosítás: | 2025. ápr. 15. 10:32 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/86947 |
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