Sarbu Mirela and Ica Raluca and Biricioiu Roxana and Clemmer David E. and Zamfir Alina D.: Mass spectrometry-based insights into human brain ganglioside dynamics in health and neurological disorders.
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Abstract
Gangliosides (GGs), glycosphingolipids abundant in the central nervous system (CNS), regulate neural development and signaling, making them valuable as biomarkers and therapeutic targets. Due to their involvement in neural development and signaling, GGs are valuable indicators for the early diagnosis of CNS pathologies. We report a nanoelectrospray ionization (nanoESI) ion mobility spectrometry (IMS) mass spectrometry (MS) and collisioninduced dissociation (CID) tandem MS platform for high-resolution CNS glycolipidomics. Applied to brain tissues, tumors, and cerebrospinal fluid [1-3], this method revealed tumorassociated alterations in GG composition, including increased glycoform and ceramide diversity, enhanced sialylation, and novel acetate-modified structures. These alterations underscore GG overexpression in glioblastoma and metastases as promising diagnostic markers and therapeutic targets, establishing a powerful workflow for brain tumor and neurodegenerative disease research.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2025 |
| Volume: | 31 |
| ISBN: | 978-963-688-078-1 |
| Page Range: | pp. 34-35 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Title: | 31th International Symposium on Analytical and Environmental Problems |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2025. október 13-14. |
| Related URLs: | https://acta.bibl.u-szeged.hu/88570/ |
| Uncontrolled Keywords: | Analitikai kémia, Tömegspektrometria, Neurokémia, Biokémia |
| Additional Information: | Bibliogr.: 35. p. ; összefoglalás angol nyelven |
| Subjects: | 03. Medical and health sciences 03. Medical and health sciences > 03.01. Basic medicine |
| Date Deposited: | 2025. Nov. 07. 09:32 |
| Last Modified: | 2025. Nov. 07. 09:32 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/88612 |
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