Sarbu Mirela and Ica Raluca and Clemmer David E. and Zamfir Alina D.: Unravelling the complexity of human brain glycosaminoglycans: a study of chondroitin/dermatan sulfates by ion mobility mass spectrometry.
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Abstract
Glycosaminoglycans (GAGs), particularly chondroitin sulfate (CS) and dermatan sulfate (DS), regulate brain processes through specific sulfation motifs. We report the first application of ion mobility spectrometry (IMS) mass spectrometry (MS) to neural GAG analysis. CS/DS octamers from mouse brain were profiled, revealing separation by sulfation content and glucuronic acid type. Eighteen distinct DS-rich domains were identified, including rare under- and oversulfated motifs. IMS MS/MS further resolved isomers and uncovered unusual trisulfated and pentasulfated structures. This approach advances brain glycosaminoglycomics and highlights novel, potentially bioactive CS/DS domains.
| Item Type: | Conference or Workshop Item |
|---|---|
| Journal or Publication Title: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Date: | 2025 |
| Volume: | 31 |
| ISBN: | 978-963-688-078-1 |
| Page Range: | pp. 267-268 |
| Language: | English |
| Publisher: | University of Szeged |
| Place of Publication: | Szeged |
| Event Type: | Conference |
| Event Location: | Szeged |
| Event Dates: | 2025. október 13-14. |
| Related URLs: | https://acta.bibl.u-szeged.hu/88570/ |
| Uncontrolled Keywords: | Neurokémia, Tömegspektrometria |
| Additional Information: | Bibliogr.: 268. p. ; összefoglalás angol nyelven |
| Subjects: | 01. Natural sciences 01. Natural sciences > 01.06. Biological sciences 03. Medical and health sciences 03. Medical and health sciences > 03.01. Basic medicine |
| Date Deposited: | 2025. Nov. 10. 16:03 |
| Last Modified: | 2025. Nov. 10. 16:03 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/88690 |
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