TY  - CONF
TI  - Gangliosidomics of cephalic disorders by ion mobility mass spectrometry
KW  - Ideggyógyászat - kutatás
KW  -  Ionmobilitás tömegspektrometria
KW  -  Elektrokémia
KW  -  Biomarker-elemzés
KW  -  Lipidszerkezetek
SP  - 82
UR  - http://acta.bibl.u-szeged.hu/85672/
N2  - In this study we report on the determination of anencephaly gangliosidome by ion mobility separation (IMS) mass spectrometry (MS), introduced here for the first time in the research of cephalic disorders. Ganglioside (GG) extracts from residual brains of anencephalic fetuses in various gestational weeks were comparatively profiled by IMS MS, structurally analyzed by IMS tandem MS (MS/MS), and, finally, assessed against a native ganglioside mixture from normal fetal brain. The comparative assay disclosed variations in GG expression with fetal age and a correlation of the pattern with the developmental stage. In contrast to the normal fetal brain, the neural tissue in anencephaly was found to contain an elevated number of polysialogangliosides and a lower expression of O-Ac- and GalNAc-modified glycoforms.
T2  - 30th International Symposium on Analytical and Environmental Problems
CY  - Szeged
AV  - public
VL  - 30
ID  - acta85672
A1  -  Biricioiu Roxana
A1  -  Sarbu Mirela
A1  -  Ica Raluca
A1  -  Vukeli? Z?eljka
A1  -  Clemmer David E.
A1  -  Zamfir Alina D.
SN  - 978-963-688-009-5
M2  - Szeged
Y1  - 2024///
N1  - Bibliogr.: 84. p. ; összefoglalás angol nyelven
PB  - University of Szeged
EP  - 84
ER  -