relation: http://acta.bibl.u-szeged.hu/85737/
title: Novel fluorescent-labeled estradiol derivatives
creator:  Hlogyik Tamás
creator:  Vágvölgyi Máté
creator:  Labos Péter
creator:  Bózsity Noémi
creator:  Zupkó István
creator:  Hunyadi Attila
creator:  Mernyák Erzsébet
subject: 01. Természettudományok
subject: 01.04. Kémiai tudományok
description: The overproduction of the female sex hormone 17β-estradiol (E2) can lead to various hormone-dependent diseases, including tumors. Due to its biological activity in reproductive tissues and the nervous system, understanding its mechanisms of action and protein interactions is of significant importance. Fluorescent labeling methods are becoming increasingly favored over radiochemical techniques for making E2 detectable, as they offer more environmentally friendly alternatives. We published recently E2–BODIPY conjugates, labeled at the phenolic hydroxy function of the steroid, that retained estrogenic activity despite modifying the estradiol structure. Here we explored certain organic dyes suitable for fluorescent labeling, focusing on compounds, which provide tunable optical properties, high photostability, and physiological stability. A rhodamine, a rosamine and an aza-BODIPY dye were conjugated to an estradiol derivative bearing a four carbon-long linker at its 3-hydroxy group. We emphasized green chemistry approaches, including supercritical fluid chromatography, one-pot reactions, and microwave-assisted methods.
publisher: University of Szeged
date: 2024
type: Konferencia vagy workshop anyag
type: NonPeerReviewed
format: part
language: hu
identifier: http://acta.bibl.u-szeged.hu/85737/1/proceedings_of_isaep_2024_278-282.pdf
identifier:    Hlogyik Tamás;  Vágvölgyi Máté;  Labos Péter;  Bózsity Noémi;  Zupkó István;  Hunyadi Attila;  Mernyák Erzsébet:   Novel fluorescent-labeled estradiol derivatives.   
language: eng