TY  - CONF
AV  - public
VL  - 30
ID  - acta85737
EP  - 282
N1  - Bibliogr.: 282. p. ; ill. ; összefoglalás angol nyelven
T2  - 30th International Symposium on Analytical and Environmental Problems
TI  - Novel fluorescent-labeled estradiol derivatives
SN  - 978-963-688-009-5
KW  - Orvosbiológiai kutatás
KW  -  Biokémia
KW  -  Fluoreszcens technológia
UR  - http://acta.bibl.u-szeged.hu/85737/
M2  - Szeged
N2  - The overproduction of the female sex hormone 17?-estradiol (E2) can lead to various hormone-dependent diseases, including tumors. Due to its biological activity in reproductive tissues and the nervous system, understanding its mechanisms of action and protein interactions is of significant importance. Fluorescent labeling methods are becoming increasingly favored over radiochemical techniques for making E2 detectable, as they offer more environmentally friendly alternatives. We published recently E2?BODIPY conjugates, labeled at the phenolic hydroxy function of the steroid, that retained estrogenic activity despite modifying the estradiol structure. Here we explored certain organic dyes suitable for fluorescent labeling, focusing on compounds, which provide tunable optical properties, high photostability, and physiological stability. A rhodamine, a rosamine and an aza-BODIPY dye were conjugated to an estradiol derivative bearing a four carbon-long linker at its 3-hydroxy group. We emphasized green chemistry approaches, including supercritical fluid chromatography, one-pot reactions, and microwave-assisted methods.
Y1  - 2024///
CY  - Szeged
PB  - University of Szeged
SP  - 278
A1  -  Hlogyik Tamás
A1  -  Vágvölgyi Máté
A1  -  Labos Péter
A1  -  Bózsity Noémi
A1  -  Zupkó István
A1  -  Hunyadi Attila
A1  -  Mernyák Erzsébet
ER  -