TY  - CONF
T2  - 30th International Symposium on Analytical and Environmental Problems
Y1  - 2024///
AV  - public
PB  - University of Szeged
CY  - Szeged
A1  -  K?szegi Kristóf András
A1  -  Szabados Márton
A1  -  Sz?ll?si György
UR  - http://acta.bibl.u-szeged.hu/85747/
TI  - Mechanochemically assisted, environmentally benign heterogeneous Asymmetric Michael addition to maleimides
M2  - Szeged
VL  - 30
EP  - 317
ID  - acta85747
SN  - 978-963-688-009-5
SP  - 313
KW  - Környezetkémia
KW  -  Katalízis
N2  - Chiral N-substituted succinimides are widely used intermediates in the pharmaceutical industry. The Michael additions of various nucleophiles to maleimides results in such compounds. In the industry, since the upraise of environmental awareness, there is a huge demand of sustainable synthetic methods. Therefore, efficient alternative reaction activations are highly examined. Asymmetric catalytic processes have been developed for Michael additions to maleimides under batch conditions using organocatalysts. Our aim was to implement mechanochemical activation in these reactions because of its huge benefits over the conventional methods, i.e. the possibility of applying solvent-free conditions and the significantly reduced reaction times. We set the goal to prepare N-substituted succinimides with high yields and enantioselectivity using isobutyraldehyde as nucleophile and L-phenylalanine adsorbed on the surface of inorganic oxides (Bentolite H and Laponite RD) as heterogeneous organocatalyst. N-methylmaleimide as reactant was used to optimise the reaction and milling parameters. We also studied the structure of the catalyst using different methods to examine the deposition of L-Phe on the inorganic oxide. As a result of our studies, optimal conditions were determined to carry out the preparation of various N-substituted succinimides, which may be a significant step in the development of sustainable industrial synthetic methods.
N1  - Bibliogr.: 317. p. ; ill.
ER  -