relation: http://acta.bibl.u-szeged.hu/85768/
title: Squalenoylated nanoparticle prodrugs
creator:  Zeini Hiba
creator:  Mernyák Erzsébet
creator:  Vágvölgyi Máté
creator:  Girst Gábor
creator:  Berkecz Róbert
creator:  Hunyadi Attila
subject: 01. Természettudományok
subject: 01.04. Kémiai tudományok
description: Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly synthesized compounds were purified by HPLC to over 95% and their structures were confirmed by NMR and HRMS. The squalenoylated compounds will be used for the synthesis of self-assembling nanoparticles, which will be subjected to investigation of their antiproliferative activity. This approach may enhance the stability and biological activity of the lead compound, advancing its therapeutic potential.
publisher: University of Szeged
date: 2024
type: Konferencia vagy workshop anyag
type: NonPeerReviewed
format: part
language: hu
identifier: http://acta.bibl.u-szeged.hu/85768/1/proceedings_of_isaep_2024_386-387.pdf
identifier:    Zeini Hiba;  Mernyák Erzsébet;  Vágvölgyi Máté;  Girst Gábor;  Berkecz Róbert;  Hunyadi Attila:   Squalenoylated nanoparticle prodrugs.   
language: eng