%0 Conference Paper
%A  Zeini Hiba
%A  Mernyák Erzsébet
%A  Vágvölgyi Máté
%A  Girst Gábor
%A  Berkecz Róbert
%A  Hunyadi Attila
%B 30th International Symposium on Analytical and Environmental Problems
%C Szeged
%D 2024
%F acta:85768
%I University of Szeged
%K Biokémia, Nanotechnológia, Gyógyszerkémia
%P 386-387
%T Squalenoylated nanoparticle prodrugs
%U http://acta.bibl.u-szeged.hu/85768/
%V 30
%X Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly synthesized compounds were purified by HPLC to over 95% and their structures were confirmed by NMR and HRMS. The squalenoylated compounds will be used for the synthesis of self-assembling nanoparticles, which will be subjected to investigation of their antiproliferative activity. This approach may enhance the stability and biological activity of the lead compound, advancing its therapeutic potential.
%Z Bibliogr.: 387. p. ; ill. ; összefoglalás angol nyelven