TY  - CONF
T2  - 30th International Symposium on Analytical and Environmental Problems
Y1  - 2024///
AV  - public
PB  - University of Szeged
CY  - Szeged
A1  -  Zeini Hiba
A1  -  Mernyák Erzsébet
A1  -  Vágvölgyi Máté
A1  -  Girst Gábor
A1  -  Berkecz Róbert
A1  -  Hunyadi Attila
UR  - http://acta.bibl.u-szeged.hu/85768/
TI  - Squalenoylated nanoparticle prodrugs
M2  - Szeged
VL  - 30
EP  - 387
ID  - acta85768
SN  - 978-963-688-009-5
SP  - 386
KW  - Biokémia
KW  -  Nanotechnológia
KW  -  Gyógyszerkémia
N2  - Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly synthesized compounds were purified by HPLC to over 95% and their structures were confirmed by NMR and HRMS. The squalenoylated compounds will be used for the synthesis of self-assembling nanoparticles, which will be subjected to investigation of their antiproliferative activity. This approach may enhance the stability and biological activity of the lead compound, advancing its therapeutic potential.
N1  - Bibliogr.: 387. p. ; ill. ; összefoglalás angol nyelven
ER  -