%D 2024
%O Bibliogr.: 387. p. ; ill. ; ĂśsszefoglalĂĄs angol nyelven
%C Szeged
%L acta85768
%T Squalenoylated nanoparticle prodrugs
%V 30
%A  Zeini Hiba
%A  MernyĂĄk ErzsĂŠbet
%A  VĂĄgvĂślgyi MĂĄtĂŠ
%A  Girst GĂĄbor
%A  Berkecz RĂłbert
%A  Hunyadi Attila
%K BiokĂŠmia, NanotechnolĂłgia, GyĂłgyszerkĂŠmia
%P 386-387
%J Proceedings of the International Symposium on Analytical and Environmental Problems
%I University of Szeged
%X Self-assembling drug conjugates offer a promising strategy in cancer therapy by forming prodrugs through hydrolysable conjugation with inducers like squalene. In this study, selfassembling squalenoylated conjugates were prepared aimed at improving bioavailability and anti-tumor efficacy. The newly synthesized compounds were purified by HPLC to over 95% and their structures were confirmed by NMR and HRMS. The squalenoylated compounds will be used for the synthesis of self-assembling nanoparticles, which will be subjected to investigation of their antiproliferative activity. This approach may enhance the stability and biological activity of the lead compound, advancing its therapeutic potential.