Pivarcsik Tamás; Dömötör Orsolya; Mészáros János P.; May Nóra V.; Csuvik Oszkár; Fülöp Ferenc; Spengler Gabriella; Szatmári István; Enyedy Éva Anna: Anticancer 8-hydroxyquinoline-amino acid hybrids and their half-sandwich Ru and Rh complexes : solution chemistry and interaction with biomolecules.
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Absztrakt (kivonat)
Development of novel chemotherapeutic agents aims to obtain more effective and selective compounds. Platinum(II)-containing chemotherapeutics have been widely used for decades in cancer therapy against solid tumors due to their effectiveness; although, their use is accompanied by drawbacks such the serious side-effects and resistance [1]. To overcome these problems, efforts have been made to find better alternatives such as the complexes of other platinum metals. 8-hydroxyquinolines and their metal complexes are widely investigated due to their anticancer properties [2,3]; however, they often have limited water solubility. In this work two novel water-soluble 8-hydroxyquinoline-D-amino acid hybrids, [(R)-1-((5-chloro-8- hydroxyquinolin-7-yl)methyl)pyrrolidine-2-carboxylic acid (8HQCl-D-Pro) and its homologue 8HQCl-D-hPro (Chart 1), and their [Ru(η6 -p-cymene)(H2O)3] 2+ and [Rh(η5 -C5Me5)(H2O)3] 2+ complexes were developed.
| Mű típusa: | Konferencia vagy workshop anyag |
|---|---|
| Befoglaló folyóirat/kiadvány címe: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Dátum: | 2020 |
| Kötet: | 26 |
| ISBN: | 978-963-306-771-0 |
| Oldalak: | pp. 289-291 |
| Nyelv: | angol |
| Konferencia neve: | International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged) |
| Befoglaló mű URL: | http://acta.bibl.u-szeged.hu/73792/ |
| Kulcsszavak: | Kémia |
| Megjegyzések: | Bibliogr.: 291. p. ; összefoglalás angol nyelven |
| Szakterület: | 01. Természettudományok 01. Természettudományok > 01.04. Kémiai tudományok |
| Feltöltés dátuma: | 2021. nov. 18. 10:03 |
| Utolsó módosítás: | 2022. aug. 08. 15:39 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/74017 |
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