Anticancer 8-hydroxyquinoline-amino acid hybrids and their half-sandwich Ru and Rh complexes : solution chemistry and interaction with biomolecules

Pivarcsik Tamás; Dömötör Orsolya; Mészáros János P.; May Nóra V.; Csuvik Oszkár; Fülöp Ferenc; Spengler Gabriella; Szatmári István; Enyedy Éva Anna: Anticancer 8-hydroxyquinoline-amino acid hybrids and their half-sandwich Ru and Rh complexes : solution chemistry and interaction with biomolecules.

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Development of novel chemotherapeutic agents aims to obtain more effective and selective compounds. Platinum(II)-containing chemotherapeutics have been widely used for decades in cancer therapy against solid tumors due to their effectiveness; although, their use is accompanied by drawbacks such the serious side-effects and resistance [1]. To overcome these problems, efforts have been made to find better alternatives such as the complexes of other platinum metals. 8-hydroxyquinolines and their metal complexes are widely investigated due to their anticancer properties [2,3]; however, they often have limited water solubility. In this work two novel water-soluble 8-hydroxyquinoline-D-amino acid hybrids, [(R)-1-((5-chloro-8- hydroxyquinolin-7-yl)methyl)pyrrolidine-2-carboxylic acid (8HQCl-D-Pro) and its homologue 8HQCl-D-hPro (Chart 1), and their [Ru(η6 -p-cymene)(H2O)3] 2+ and [Rh(η5 -C5Me5)(H2O)3] 2+ complexes were developed.

Mű típusa: Konferencia vagy workshop anyag
Befoglaló folyóirat/kiadvány címe: Proceedings of the International Symposium on Analytical and Environmental Problems
Dátum: 2020
Kötet: 26
ISBN: 978-963-306-771-0
Oldalak: pp. 289-291
Nyelv: angol
Konferencia neve: International Symposium on Analytical and Environmental Problems (26.) (2020) (Szeged)
Befoglaló mű URL: http://acta.bibl.u-szeged.hu/73792/
Kulcsszavak: Kémia
Megjegyzések: Bibliogr.: 291. p. ; összefoglalás angol nyelven
Szakterület: 01. Természettudományok
01. Természettudományok > 01.04. Kémiai tudományok
Feltöltés dátuma: 2021. nov. 18. 10:03
Utolsó módosítás: 2022. aug. 08. 15:39
URI: http://acta.bibl.u-szeged.hu/id/eprint/74017
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