Costinas Ioana; Cretu Carmen; Tudose Ramona; Cseh Liliana; Sasca Viorel; Badea Valentin; Costisor Otilia; Szerb Elisabeta I.: Homoleptic and heteroleptic pt(II) complexes with potential biological activity.
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Absztrakt (kivonat)
Metal complexes used as pharmaceuticals have received great attention because of their potential biological activity. The chemistry of platinum(II) complexes has been widely developed since the cytostatic activity of cis-diaminodichloroplatinum(II) (cisplatin) has been discovered [1]. Moreover, transition metal complexes containing planar polycyclic aromatic systems intercalate between the stacked base pairs of DNA. The biological activity of both cis- and trans-diamine Pt(II) complexes is dramatically enhanced by the presence of aromatic intercalator ligands, due to the influence on both kinetics and thermodynamics of DNA binding [2,3]. The chemistry of Pt(II) complexes is highly versatile, permitting the design and synthesis of a large variety of different structures. By ‘smart’ molecular engineering, new structures are programmed and obtained continuously, in an attempt to overcome the drawbacks of the cisplatinum like tumor resistance, or to lessening unpredictable and severe nephrotoxicity and/or providing oral bioavailability. Herein, new Pt(II) complexes as DNA intercalators were synthesized and characterized aiming to follow their structure – activity relationships. The synthesis and characterization of the complexes will be presented.
| Mű típusa: | Konferencia vagy workshop anyag |
|---|---|
| Befoglaló folyóirat/kiadvány címe: | Proceedings of the International Symposium on Analytical and Environmental Problems |
| Dátum: | 2015 |
| Kötet: | 21 |
| ISBN: | 978-963-306-411-5 |
| Oldalak: | p. 17 |
| Konferencia neve: | International Symposium on Analytical and Environmental Problems (21.) (2015) (Szeged) |
| Befoglaló mű URL: | http://acta.bibl.u-szeged.hu/55892/ |
| Kulcsszavak: | Kémia - előadáskivonat |
| Megjegyzések: | Bibliogr.: 17. p. |
| Feltöltés dátuma: | 2018. dec. 05. 08:55 |
| Utolsó módosítás: | 2022. aug. 08. 15:47 |
| URI: | http://acta.bibl.u-szeged.hu/id/eprint/55918 |
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