Identification of the main metabolites of three synthetic cannabinoids using LC-MS/MS technique

Körmöczi Tímea; Sija Éva; Berkecz Róbert: Identification of the main metabolites of three synthetic cannabinoids using LC-MS/MS technique.

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The consumption of designer drugs today is a serious problem, especially among young people involvement. ‘Herbal mixtures’ containing synthetic cannabinoids (SCs) that mimic the effect of marijuana and there are easily available via the Internet. For analysis of urine samples, knowledge of the main metabolites is necessary as the mother compounds are usually not found in urine after using, due to their fast metabolism. The aims of this study were the in vitro identification of metabolites of ADB-FUBINACA, 5F-MDMB-PICA and CUMYL-PEGACLONE and to determine which analytical targets are excreted into urine. Metabolites identified after incubation of SCs with pooled human liver microsomes (HLM). The authentic urine samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for investigation of the major in vivo metabolites. The main metabolites were the mono-hydroxylation of ADB-FUBINACA and CUMYL-PEGACLONE in positive urine specimens. We didn’t have positive sample of 5F-MDMB-PICA.

Mű típusa: Konferencia vagy workshop anyag
Befoglaló folyóirat/kiadvány címe: Proceedings of the International Symposium on Analytical and Environmental Problems
Dátum: 2018
Kötet: 24
ISBN: 978-963-306-623-2
Oldalak: pp. 316-319
Konferencia neve: International Symposium on Analytical and Environmental Problems (24.) (2018) (Szeged)
Befoglaló mű URL: http://acta.bibl.u-szeged.hu/55895/
Kulcsszavak: Növénykémia, Analitikai kémia
Megjegyzések: Bibliogr.: 319. p. ; összefoglalás angol nyelven
Feltöltés dátuma: 2019. jan. 08. 08:31
Utolsó módosítás: 2022. aug. 08. 15:50
URI: http://acta.bibl.u-szeged.hu/id/eprint/56359
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